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PEA guards towards bacterial an infection by means of innate immune modulation involving MCs, macrophages and microglia. Prophylactic PEA at a dose of 0.one mg/kg human body fat prolonged survival fee and reduced neuro-inflammation within an aged murine bacterial meningitis product, in the absence of antibiotics [42].The latter is of Specific curio

2015). These research, taken alongside one another, propose that, Whilst a immediate activation of GPR55 or PPAR?? takes place, PEA can generate its anti?inflammatory action from the intestine also via oblique activation of CB1 and CB2 receptors, in all probability as a consequence of the flexibility of this compound to potentiate the action of end